Jobs

The Pharmacogenetics of Anticancer Agents Research (PAAR) Group is actively engaged in the discovery of molecular genetic variation contributing to variation in response to anticancer agents. As part of the NIH Pharmacogenetic Research Network, investigators at the University of Chicago, St. Jude Children's Research Hospital in Memphis and the University of Pittsburgh are investigating polymorphisms contributing to interindividual differences in metabolism, transport, and pharmacodynamics of cancer chemotherapeutic agents.

The University of Chicago is an Equal Opportunity Employer.
St. Jude Children's Research Hospital is an Equal Opportunity Employer.

Current Positions Available:

The University of Chicago

Postdoctoral position/Molecular Biology

An NIH-funded postdoctoral position is available immediately in the Department of Medicine at the University of Chicago to work on the analysis genetic determinants responsible for variable drug response using International HapMap cell lines. Possible projects will include genome wide association analysis to predict polymorphic variants that affect gene expression or function. The information arising from these projects will be used to design functional molecular studies to validate candidate genes using siRNA. The postdoctoral fellow will be part of a multi-institutional research group on the study of the pharmacogenetics of anticancer agents (http://www.pharmacogenetics.org) that involves frequent interactions with a broad range of scientists with expertise in human genetics, bioinformatics, clinical pharmacology and molecular pharmacology.

Experience in molecular biology and/or genetics is expected and working with genome databases, and/or bioinformatics tools is highly desirable. The Department of Medicine at the University of Chicago provide a stimulating and interactive environment with several labs interested in diverse aspects of human variation, statistical and computational genetics, cancer genetics and clinical pharmacology. Please note that applicants with more than four years prior postdoctoral training will not be considered at this time.

The University of Chicago is an Equal Opportunity Employer.

Applicants should send a curriculum vitae, a one-page letter describing their prior research experience, current interests and goals, and should provide names and contact information of three references to:

Dr. M. Eileen Dolan
The University of Chicago
Email: edolan@medicine.bsd.uchicago.edu

The University of Chicago

Data Manager or Statistician

The University of Chicago seeks full-time Data Manager/Statistician to be part of the Pharmacogenetics of Anticancer Agents (PAAR) Group. Specific responsibilities include (1) database management of generated phenotypic and genotypic data, (2) implementation of systems to facilitate project management between laboratories involved in phenotypic/genetic data collection, (3) statistical analysis of relationship between phenotypes and genotypes, (4) use of available databases and database programs for searches to identify genomic structures of genes, homologous family members of genes etc, for genes of interest to the PAAR group, (5) use of sequencing analysis programs to identify variants and indicate quality of sequencing coverage, (6) maintenance of a system to track development of each project from design to completion, and (7) analysis of linkage disequilibrium among variants.

Experience with data management and familiarity with basic applications are highly desirable. Candidates with a B.S. in Bioinformatics/Statistics or related discipline are invited to apply.

The University of Chicago is an Equal Opportunity Employer.

Applicants should forward their resume to:

Mark J Ratain, MD
The University of Chicago
Chair, Pharmacogenetics of Anticancer Agents Research Group
Email: mratain@medicine.bsd.uchicago.edu

The University of Chicago

Postdoctoral Scholar - Pharmacogenetics/Genomics

A postdoctoral scholar is needed for conducting pharmacogenetics/genomics studies of anti-cancer drugs. The project focuses on investigating the functionality and regulation of hepatic genes and the roles of genetic polymorphisms in drug metabolism, transport and disposition. Candidates should have a Ph.D. in genetics/molecular genetics/pharmacology/biochemistry with experience in phenotyping of drug metabolism. Specific skills required for the position include: enzyme activity assays, HPLC, PCR and genotyping, data analysis and statistics. Other desired skills include microarray data analysis, luciferase assay, EMSA, real-time PCR and cytotoxicity studies.

Candidates should submit a CV, statement of research interests, contact information of 3 references and copies of publications to:

Mark J Ratain, MD
The University of Chicago
Chair, Pharmacogenetics of Anticancer Agents Research Group
Email: mratain@medicine.bsd.uchicago.edu