PGRN Analysis Workshop IV

 

January 22 - January 23, 2008

St. Jude Children's Research Hospital,

             Memphis, TN

 

The complete agenda can be downloaded here.

The content below in Microsoft Word format can be downloaded here.

General Information

Meeting Dates and Times:

The PGRN Analysis Workshop IV will take place on Tuesday, January 22nd, 2008, from 9:00am to 5:00pm and on Wednesday, January 23rd from 9:00am to 3:00pm. 

 

Elivis

 

Format & Scientific Topics:

This is a small group, highly-interactive meeting with short oral presentations and extensive discussion. The purpose is to share state-of-the-art techniques and ideas for analysis of pharmacogenetic/genomic data. Volunteer presenters are invited to submit their name, affiliation, and title for their presentation by November 15, 2007. Depending upon the number of submissions, each participant will have either an oral or poster presentation, with talks from 15-30 minutes followed by group discussions. 

 

Participation by all PGRN groups and affiliates is encouraged.

 

Topics include but are not limited to:

Population admixture

Expression phenotypes vs genomics

Genome wide association analyses (GWA)

Validation and meta (combined) analysis for GWA

Bayesian approaches to model selection and False Discovery Rate

Pharmacogenetics in clinical trials

SNP array normalization for inference of copy alterations and other genomic lesions

Inference of shared genomic lesions in GWA

2008 Genetic Analysis Workshop (GAW) preparation

 

We will ask for an abstract, to be handed out in a booklet to meeting attendees, by January 10, 2008. You may forward your presentation to corennea.pleasants@stjude.org by 5 pm Friday, January 18, 2008, or bring your presentation to the meeting on a flashdrive. 

 

Meeting Location:

Board Room, second floor, Shadyac-ALSAC Tower, St. Jude Children's Research Hospital (SJCRH)

332 N. Lauderdale Street, Memphis, TN  38105.

Parking is available on site at SJCRH campus for those of you who wish to drive/or have a rental car. 

 

Meeting Fee:

 

The $95 registration fee is due by Thursday, November 15, 2007 and includes admission to the two day workshop, 2 breakfasts, 2 refreshment breaks, and 2 lunches. Registration for trainees (post docs and students) is free.

 

Tuesday Night Group Dinner:

 

Please meet in the hotel lobby at 6:30 PM. In addition to the Main Street trolley line and transportation provided by our postdoctoral volunteers from the hotel to dinner location, a shuttle will be available at 6:30 PM for ride to the restaurant.

 

Dinner is at Harry’s Detour South Main (106 GE Patterson.) to start at 6:45-7:00 PM.

 

Audiovisual:

An LCD projector and computer (PC), overhead projector, microphone and laser pointer will be available.  Your presentation should be in Microsoft PowerPoint or PDF format.

 

Travel Arrangements:

Please make arrangements to fly into Memphis International Ariport. 

 

Transportation:

Attendees are responsible for their own transportation to the Marriott hotel upon arrival in Memphis. Taxis from the airport one-way run ~ $25 - $30. 

 

Shuttle service from the hotel to St. Jude will be provided by St. Jude security staff on Tuesday and Wednesday mornings on this schedule:

 

Pick up at Marriott     7:45 AM

8:00 AM

8:15 AM

 

Please note:  If it is nice weather and for those who like to, the Marriott is an approximately 8 minute walk from St. Jude. Please ask Marriott staff for directions, and enter in the main entrance for the Patient Care Center.

 

Upon arrival at St. Jude, we will have volunteers positioned in the lobby of the Patient Care Entrance to direct you to the Board Room, which is on the 2nd floor of the Shadyac/ALSAC Tower.

 

If you will be driving to the campus, St. Jude security guards will direct you to parking and the Patient Care Entrance.

 

Shuttle service from St. Jude (at the Patient Care Center entrance) to the hotel will be provided by St. Jude security staff on Tuesday afternoon at:

5:30 PM

                             5:45 PM 

 

Hotel Information:

Hotel reservations must be made by individual attendees directly with the Memphis Marriott Downtown , 250 North Main Street, Memphis, TN   38103, at (888) 557-8740 or (901) 527-7300 .

Please identify yourself as a member of the Group, 'PGRN Analysis Workshop IV-Memphis-St. Jude' for the room rate of $104.00 per night. All reservations must be guaranteed with a major credit card. The reservations should be made by November 15th in order to secure the group rate.

 

Hotel Parking:

Guest parking is available at the Marriott - Valet parking is $18.00 and self-parking is $12.00 per day.

 

Internet:

We’ve arranged for wireless internet access for attendees and will provide logon details in handouts which will be available in the Board Room on Tuesday morning.

 

Cancellations:

 

A full refund is available if cancellation is received prior to November 15th.  A 50% refund if cancellation is received prior to December 15th. No refund after December 15, 2007.

 

Registrations:

For registration, please complete the information below and fax to Corennea Pleasants at (901) 525-6869 or email to corennea.pleasants@stjude.org no later than Thursday, November 15th, 2007.  The $95 registration fee is due by Thursday, November 15th, 2007 and includes admission to the two day workshop, 2 breakfasts, 2 refreshment breaks, and 2 lunches.  Complete this form and mail it along with your check made out to St. Jude Children's Research Hospital to: Corennea Pleasants . St. Jude Children's Research Hospital . 332 N. Lauderdale Street MS 313 . Memphis, TN  38105

 

First Name

 

 

Last Name

Degree

 

 

Title

 

Organization

 

 

Address 1

Address 2

 

 

Address 3

City, State, ZIP

 

 

Email

Phone

 

 

FAX

Do you plan to volunteer to give a presentation?

 

 

Title or topic:

Are you a student?

 

 

Are you a resident or post-doc?

Presentation: If you would like to make a presentation, please send an email to Corennea.pleasants@stjude.org with your name, affiliation, and title of your presentation by November 15th, 2007.

 

Agenda:

Tuesday,  January 22

8:30 – 9:00

Breakfast

 

9:00 – 9:10

Welcome, Introductions, and Agenda

Mary V. Relling, Cheng Cheng

9:10 – 9:40

Thinking about Epistasis in an era of Whole Genome Association

Marylyn Ritchie, PAT

 

9:40 – 10:00

Discussion

 

10:00 – 10:20

Exhaustive SNP Exploration: A Filter Approach for GWAs that Considers Interactions

Alison Motsinger-Reif, CREATE

10:20 – 10:35

Discussion

 

10:35 – 11:00

Break

 

11:00 – 11:20

Clinical Trial Design Considerations

Gary Rosner, PAAR

11:20 – 11:35

Discussion

 

11:35 – 11:55

Multivariate models to detect genomic  signatures for a class of drugs

Brooke Fridley, PPII

11:55 – 12:10

Discussion

 

12:10 – 1:30

Lunch

 

1:30 – 1:50

GWA of Expression Phenotypes

Emily Kistner, PAAR

1:50 – 2:05

Discussion

 

2:05 – 2:25

Multi-step variable selection strategy for large scale pharmacogenetics association studies

Andrei S. Rodin, PEAR

2:25 – 2:40

Discussion

 

2:40 – 3:00

Break

 

3:00 – 3:20

Reference Normalization Reduces Bias in Microarray Studies

Stan Pounds, PAAR

3:20 – 3:35

Discussion

 

3:35 – 3:55

Using Ontologies in Hierarchical Modeling of Genes and Exposures in Biologic Pathways

David V. Conti, PNAT

3:55 – 4:10

Discussion

 

4:10 – 4:30

Using Racial Genotypic information for Dimensionality Reduction in SNP Association studies

Kent R. Bailey, PPII

4:30 – 4:45

Discussion

 

4:45 – 5:05

Screening for Pharmacogenetic Loci in a Genome-Wide Association Study of Asthma

Amy Murphy, PHAT

5:05 – 5:20

Discussion

 

5:20 – 5:30

General Discussion:

1.        PGRN analysis review committee

2.        Analysis working group presentation at upcoming PGRN meeting: posters/talks

3.        Upcoming analysis workshops

            Mayo PPII (Dr. Dick Weinshilboum) March/April’09

            Planning committee

4.        Sign up for PGRN-RIP seminars

            Second Friday 2:00 each month; March, June, Fall

5.     Group report to ESP(?) in Spring

6.        An on-line PGRN data analysis Forum (Journal Club)?

PGRN internal data analysis RIP tech reports (on-line)?

 

5:30

Adjourn

 

 

DINNER GROUPS - Join a group of PGRN AWS-IV attendees at one of several of Memphis’ finest restaurants by

signing up on the meeting check-in table.  Meet in the main lobby of the Marriott at 6:30 pm.  Reservations will be

made.

 

Wednesday, January 23

8:30 – 9:00

Breakfast

 

9:00 – 9:30

Second and Third Stage Analyses for Genome-wide Association Studies

Nancy Cox, PAAR

9:30 – 9:50

Discussion

 

9:50 – 10:20

Race/Ethnicity and Pharmacogenetic Research and Clinical Practice

Esteban Gonzalez Burchard

10:20 – 10:40

Discussion

 

10:40 – 11:00

Break

 

11:00 – 11:30

ENDGAME: Enhancing Development of Genome-Wide Association Methods

Goncalo Abecasis, ENDGAME

11:30 –11:50

Discussion

 

11:50 – 1:30

Lunch

 

1:30 – 1:50

Validation inference and combined analysis in genome wide association studies

Cheng Cheng, PAAR

1:50 – 2:05

Discussion

 

2:05 – 3:00

General Discussion:

1.        PGRN analysis review committee

2.        Analysis working group presentation at upcoming PGRN meeting: posters/talks

3.        Upcoming analysis workshops

            Mayo PPII (Dr. Dick Weinshilboum) March/April’09

            Planning committee

4.        Sign up for PGRN-RIP seminars

            Second Friday 2:00 each month; March, June, Fall

5.        Group report to ESP(?) in Spring

6.        An on-line PGRN data analysis Forum (Journal Club)?

7.        PGRN internal data analysis RIP tech reports (on-line)?

 

3:00

Adjourn

 

 

Contact Information:

 

If there are any problems, please feel free to call one of us:

 

Dr. Mary Relling office phone:  901/495-2348

Cell phone: 901/428-6903    

Administrative Assistant: 901/495-3663

 

Dr. Cheng Cheng office phone: 901/495-2935

Cell phone: 901/438-4548

 

We look forward to seeing you in Memphis.

 

 

Elivis